THE SMART TRICK OF PKRRATING THAT NOBODY IS DISCUSSING

The activated enzyme then phosphorylates its significant substrate, the translational initiation variable eIF2α. The resulting translational arrest blocks viral replication. PKR belongs into a conserved household of four protein kinases (PKR, PERK, GCN2, HRI) that every one phosphorylate eIF2α in response to distinctive stimuli12, triggering the